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Available evidence further supports the adverse effects of M. Pharmacological activities are mainly mediated via opioid receptors as well as neuronal Ca2 channels, expression of c AMP and CREB protein and via descending monoaminergic system. Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression.Frequent use can lead to dependence and adverse reactions, even ER visits. Kratom or its main alkaloid, mitragynine is derived from the plant Mitragyna speciosa Korth which is indigenous to Southeast Asian countries.Long-term daily high dose intake could induce anxiety, insomnia, loss of sex drive, constipation and the darkening of skin. This substance has become widely available in other countries like Europe and United States due to its opium- and coca-like effects. speciosa has been proven to have a rewarding effect and is effective in alleviating the morphine and ethanol withdrawal effects.Mitragynine is the major active alkaloid in the plant.To date, the role of mitragynine in psychological disorders such as depression is not scientifically evaluated.

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